|Other Names||B-cell antigen receptor complex-associated protein beta chain, B-cell-specific glycoprotein B29, Ig-beta, Immunoglobulin-associated B29 protein, CD79b, CD79B, B29, IGB|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.|
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Provided below are standard protocols that you may find useful for product applications.
The B lymphocyte antigen receptor is a multimeric complexthat includes the antigen-specific component, surfaceimmunoglobulin (Ig). Surface Ig non-covalently associates with twoother proteins, Ig-alpha and Ig-beta, which are necessary forexpression and function of the B-cell antigen receptor. This geneencodes the Ig-beta protein of the B-cell antigen component.Alternatively spliced transcript variants encoding differentisoforms have been described.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Liang, X.S., et al. Br. J. Haematol. 146(4):418-423(2009)
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