|Other Names||MAD2L1-binding protein, Caught by MAD2 protein, MAD2L1BP, CMT2, KIAA0110|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex.|
|Cellular Location||Nucleus. Cytoplasm, cytoskeleton, spindle. Note=During early mitosis, unevenly distributed throughout the nucleoplasm. From metaphase to anaphase, concentrated on the spindle|
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The protein encoded by this gene was identified as abinding protein of the MAD2 mitotic arrest deficient-like 1(MAD2/MAD2L1). MAD2 is a key component of the spindle checkpointthat delays the onset of anaphase until all the kinetochores areattached to the spindle. This protein may interact with the spindlecheckpoint and coordinate cell cycle events in late mitosis.Alternatively spliced transcript variants encoding distinctisoforms have been observed.
Yun, M., et al. Mol. Cancer Res. 7(3):371-382(2009)Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)Yang, M., et al. Cell 131(4):744-755(2007)Yun, M.Y., et al. Exp. Mol. Med. 39(4):508-513(2007)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
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