|Other Names||Nuclear pore complex protein Nup50, 50 kDa nucleoporin, Nuclear pore-associated protein 60 kDa-like, Nucleoporin Nup50, NUP50, NPAP60L|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the nuclear pore complex that has a direct role in nuclear protein import. Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin- alpha:beta-cargo complex and importin recycling. Interacts with multiple transport receptor proteins including CDKN1B. This interaction is required for correct intracellular transport and degradation of CDKN1B.|
|Cellular Location||Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Localizes to the nucleoplasmic fibrils of the nuclear pore complex (By similarity). Dissociates from the NPC structure early during prophase of mitosis. Associates to the newly formed nuclear membrane during telophase.|
|Tissue Location||Ubiquitous. Highest levels in testis, peripheral blood leukocytes and fetal liver|
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The nuclear pore complex is a massive structure thatextends across the nuclear envelope, forming a gateway thatregulates the flow of macromolecules between the nucleus and thecytoplasm. Nucleoporins are the main components of the nuclear porecomplex in eukaryotic cells. The protein encoded by this gene is amember of the FG-repeat containing nucleoporins that functions as asoluble cofactor in importin-alpha:beta-mediated nuclear proteinimport. Pseudogenes of this gene are found on chromosomes 5, 6, and14. Two transcript variants encoding different isoforms have beenfound for this gene.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Ogawa, Y., et al. Mol. Biol. Cell 21(4):630-638(2010)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)
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