|Other Names||Beta-1, 4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III, GNT-III, GlcNAc-T III, N-acetylglucosaminyltransferase III, MGAT3, GGNT3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides.|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
There are believed to be over 100 differentglycosyltransferases involved in the synthesis of protein-bound andlipid-bound oligosaccharides. The enzyme encoded by this genetransfers a GlcNAc residue to the beta-linked mannose of thetrimannosyl core of N-linked oligosaccharides and produces abisecting GlcNAc. Multiple alternatively spliced variants, encodingthe same protein, have been identified.
Benson, V., et al. Int. Immunol. 22(3):167-177(2010)Akasaka-Manya, K., et al. Glycobiology 20(1):99-106(2010)Pinho, S.S., et al. Hum. Mol. Genet. 18(14):2599-2608(2009)Sato, Y., et al. J. Biol. Chem. 284(18):11873-11881(2009)Fiala, M., et al. Proc. Natl. Acad. Sci. U.S.A. 104(31):12849-12854(2007)
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