|Other Names||PR domain zinc finger protein 8, 211-, PR domain-containing protein 8, PRDM8, PFM5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Probable histone methyltransferase, preferentially acting on 'Lys-9' of histone H3 (By similarity). Involved in the control of steroidogenesis through transcriptional repression of steroidogenesis marker genes such as CYP17A1 and LHCGR (By similarity). Forms with BHLHE22 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation (By similarity). In the retina, it is required for rod bipolar and type 2 OFF-cone bipolar cell survival (By similarity).|
|Tissue Location||Expressed in brain, heart, skeletal muscle, testes, prostate.|
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Provided below are standard protocols that you may find useful for product applications.
PRDM8 may be involved in transcriptional regulation.
Newton-Cheh, C., et al. Nat. Genet. (2009) In press :Xiao, B., et al. Curr. Opin. Struct. Biol. 13(6):699-705(2003)Jiang, G.L., et al. Histol. Histopathol. 15(1):109-117(2000)
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