Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
ARHGEF6 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q15052 |
|---|---|
| Clone Names | 100623053 |
| Gene ID | 9459 |
|---|---|
| Other Names | Rho guanine nucleotide exchange factor 6, Alpha-Pix, COOL-2, PAK-interacting exchange factor alpha, Rac/Cdc42 guanine nucleotide exchange factor 6, ARHGEF6, COOL2, KIAA0006, PIXA |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ARHGEF6 |
|---|---|
| Synonyms | COOL2, KIAA0006, PIXA |
| Function | Acts as a RAC1 guanine nucleotide exchange factor (GEF). |
| Cellular Location | Cell projection, lamellipodium. |
| Tissue Location | Ubiquitous. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Rho GTPases play a fundamental role in numerous cellularprocesses that are initiated by extracellular stimuli that workthrough G protein coupled receptors. The encoded protein belongs toa family of cytoplasmic proteins that activate the Ras-like familyof Rho proteins by exchanging bound GDP for GTP. It may form acomplex with G proteins and stimulate Rho-dependent signals. Thisprotein is activated by PI3-kinase. Mutations in this gene cancause X-chromosomal non-specific mental retardation. [provided byRefSeq].
References
Maiti, A.K. Pharmacogenomics J. 10(2):94-104(2010)Eriguchi, M., et al. J. Neurol. Sci. 290 (1-2), 80-85 (2010) :Takefuji, M., et al. J. Hum. Genet. 55(1):42-49(2010)Lim, J.W., et al. Scand. J. Gastroenterol. 44(10):1166-1172(2009)Baek, H.Y., et al. Ann. N. Y. Acad. Sci. 1096, 18-23 (2007) :
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
