|Other Names||Rho guanine nucleotide exchange factor 6, Alpha-Pix, COOL-2, PAK-interacting exchange factor alpha, Rac/Cdc42 guanine nucleotide exchange factor 6, ARHGEF6, COOL2, KIAA0006, PIXA|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||COOL2, KIAA0006, PIXA|
|Function||Acts as a RAC1 guanine nucleotide exchange factor (GEF).|
|Cellular Location||Cell projection, lamellipodium|
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Rho GTPases play a fundamental role in numerous cellularprocesses that are initiated by extracellular stimuli that workthrough G protein coupled receptors. The encoded protein belongs toa family of cytoplasmic proteins that activate the Ras-like familyof Rho proteins by exchanging bound GDP for GTP. It may form acomplex with G proteins and stimulate Rho-dependent signals. Thisprotein is activated by PI3-kinase. Mutations in this gene cancause X-chromosomal non-specific mental retardation. [provided byRefSeq].
Maiti, A.K. Pharmacogenomics J. 10(2):94-104(2010)Eriguchi, M., et al. J. Neurol. Sci. 290 (1-2), 80-85 (2010) :Takefuji, M., et al. J. Hum. Genet. 55(1):42-49(2010)Lim, J.W., et al. Scand. J. Gastroenterol. 44(10):1166-1172(2009)Baek, H.Y., et al. Ann. N. Y. Acad. Sci. 1096, 18-23 (2007) :
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