|Other Names||Membrane protein FAM174A, Hepatitis C virus NS5A-transactivated protein 6, HCV NS5A-transactivated protein 6, Transmembrane protein 157, FAM174A, NS5ATP6, TMEM157|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
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TMEM157 (transmembrane protein 157), also known as membrane protein FAM174A and hepatitis C virus NS5A-transactivated protein 6, is 190 amino acid protein encoded by a gene mapping to human chromosome 5. With 181 million base pairs encoding around 1,000 genes, chromosome 5 is about 6% of human genomic DNA. It is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5 associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome. Deletion of 5q or chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.
Otowa, T., et al. J. Hum. Genet. 54(2):122-126(2009)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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