|Other Names||Keratin, type II cytoskeletal 3, 65 kDa cytokeratin, Cytokeratin-3, CK-3, Keratin-3, K3, Type-II keratin Kb3, KRT3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Cornea specific.|
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The protein encoded by this gene is a member of thekeratin gene family. The type II cytokeratins consist of basic orneutral proteins which are arranged in pairs of heterotypic keratinchains coexpressed during differentiation of simple and stratifiedepithelial tissues. This type II cytokeratin is specificallyexpressed in the corneal epithelium with family member KRT12 andmutations in these genes have been associated with Meesmann'sCorneal Dystrophy. The type II cytokeratins are clustered in aregion of chromosome 12q12-q13.
Szaflik, J.P., et al. Mol. Vis. 14, 1713-1718 (2008) :Schweizer, J., et al. J. Cell Biol. 174(2):169-174(2006)Chen, Y.T., et al. Cornea 24(8):928-932(2005)Rogers, M.A., et al. J. Invest. Dermatol. 124(3):536-544(2005)Irvine, A.D., et al. Nat. Genet. 16(2):184-187(1997)
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