|Other Names||Kv channel-interacting protein 4, KChIP4, A-type potassium channel modulatory protein 4, Calsenilin-like protein, Potassium channel-interacting protein 4, KCNIP4, CALP, KCHIP4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner (PubMed:11847232, PubMed:18957440, PubMed:23576435). Modulates KCND3/Kv4.3 currents (PubMed:23576435). Isoform 4 does not increase KCND2 expression at the cell membrane (PubMed:18957440). Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane.|
|Cellular Location||Cell membrane; Peripheral membrane protein Cytoplasm|
|Tissue Location||Predominantly expressed in brain.|
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This gene encodes a member of the family of voltage-gatedpotassium (Kv) channel-interacting proteins (KCNIPs), which belongto the recoverin branch of the EF-hand superfamily. Members of theKCNIP family are small calcium binding proteins. They all haveEF-hand-like domains, and differ from each other in the N-terminus.They are integral subunit components of native Kv4 channelcomplexes. They may regulate A-type currents, and hence neuronalexcitability, in response to changes in intracellular calcium. Thisprotein member also interacts with presenilin. Multiplealternatively spliced transcript variants encoding distinctisoforms have been identified for this gene.
Horinouchi, M., et al. Pediatr Hematol Oncol 27(5):344-354(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Lin, L., et al. Mol. Cell. Neurosci. 43(3):315-325(2010)Ding, H., et al. Stroke 41(1):177-180(2010)Trynka, G., et al. Gut 58(8):1078-1083(2009)
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