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ZDHHC8 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9ULC8 |
|---|---|
| Clone Names | 100528194 |
| Gene ID | 29801 |
|---|---|
| Other Names | Probable palmitoyltransferase ZDHHC8, Zinc finger DHHC domain-containing protein 8, DHHC-8, Zinc finger protein 378, ZDHHC8, KIAA1292, ZDHHCL1, ZNF378 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ZDHHC8 (HGNC:18474) |
|---|---|
| Function | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (Probable). Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (Probable). Could also play a role in glutamatergic transmission (By similarity). |
| Cellular Location | Golgi apparatus membrane; Multi-pass membrane protein. Mitochondrion membrane {ECO:0000250|UniProtKB:Q5Y5T5}; Multi-pass membrane protein |
| Tissue Location | Widely expressed.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a four transmembrane protein that is amember of the zinc finger DHHC domain-containing protein family.The encoded protein may function as a palmitoyltransferase. Defectsin this gene may be associated with a susceptibility toschizophrenia. Alternate splicing of this gene results in multipletranscript variants. A pseudogene of this gene is found onchromosome 22.
References
Shin, H.D., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (6), 1167-1172 (2010) :Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :Xu, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2010) In press :Yang, W., et al. Mol. Cell Proteomics 9(1):54-70(2010)Singaraja, R.R., et al. Circ. Res. 105(2):138-147(2009)
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