|Other Names||Signaling threshold-regulating transmembrane adapter 1, SHP2-interacting transmembrane adapter protein, Suppression-inducing transmembrane adapter 1, gp30/40, SIT1, SIT|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells. Involved in positive selection of T-cells.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Specifically expressed in T- and B-cells. Present in plasma cells but not in germinal center B-cells (at protein level). Expressed in T- and B-cell lymphoma|
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Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells. Involved in positive selection of T-cells.
Chapuis, J., et al. Mol. Psychiatry 14(11):1004-1016(2009)Tedoldi, S., et al. Blood 107(1):213-221(2006)Tao, W.A., et al. Nat. Methods 2(8):591-598(2005)Tao, W.A., et al. Nat. Methods 2(8):591-598(2005)Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)
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