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EIF3K Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9UBQ5
Clone Names 100528321
Peptide ID 100528321
Additional Information
Gene ID 27335
Other Names Eukaryotic translation initiation factor 3 subunit K {ECO:0000255|HAMAP-Rule:MF_03010}, eIF3k {ECO:0000255|HAMAP-Rule:MF_03010}, Eukaryotic translation initiation factor 3 subunit 12 {ECO:0000255|HAMAP-Rule:MF_03010}, Muscle-specific gene M9 protein, PLAC-24, eIF-3 p25 {ECO:0000255|HAMAP-Rule:MF_03010}, eIF-3 p28, EIF3K {ECO:0000255|HAMAP-Rule:MF_03010}
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name EIF3K {ECO:0000255|HAMAP-Rule:MF_03010}
Function Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF- 3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
Cellular Location Nucleus {ECO:0000255|HAMAP-Rule:MF_03010, ECO:0000269|PubMed:15327989}. Cytoplasm {ECO:0000255|HAMAP- Rule:MF_03010, ECO:0000269|PubMed:15327989}
Tissue Location Ubiquitous, with the highest levels of expression in brain, testis and kidney
Research Areas
Citations (0)

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The 700-kD eukaryotic translation initiation factor-3(eIF3) is the largest eIF and contains at least 12 subunits,including EIF2S12. eIF3 plays an essential role in translation bybinding directly to the 40S ribosomal subunit and promotingformation of the 40S preinitiation complex (Mayeur et al., 2003[PubMed 14519125]).


Zhou, M., et al. Proc. Natl. Acad. Sci. U.S.A. 105(47):18139-18144(2008)Lin, Y.M., et al. J. Cell. Sci. 121 (PT 14), 2382-2393 (2008) :Masutani, M., et al. EMBO J. 26(14):3373-3383(2007)Damoc, E., et al. Mol. Cell Proteomics 6(7):1135-1146(2007)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :

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$ 80.00
Cat# BP16788b
Availability: In Stock
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