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UBE2B Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P63146
Clone Names 100617102
Peptide ID 100617102
Additional Information
Gene ID 7320
Other Names Ubiquitin-conjugating enzyme E2 B, RAD6 homolog B, HR6B, hHR6B, Ubiquitin carrier protein B, Ubiquitin-conjugating enzyme E2-17 kDa, Ubiquitin-protein ligase B, UBE2B, RAD6B
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name UBE2B
Synonyms RAD6B
Function Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys- 164'. May be involved in neurite outgrowth.
Cellular Location Cell membrane. Nucleus. Note=In peripheral neurons, expressed both at the plasma membrane and in nuclei.
Research Areas
Citations (0)

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The modification of proteins with ubiquitin is animportant cellular mechanism for targeting abnormal or short-livedproteins for degradation. Ubiquitination involves at least threeclasses of enzymes: ubiquitin-activating enzymes, or E1s,ubiquitin-conjugating enzymes, or E2s, and ubiquitin-proteinligases, or E3s. This gene encodes a member of the E2ubiquitin-conjugating enzyme family. This enzyme is required forpost-replicative DNA damage repair. Its protein sequence is 100%identical to the mouse, rat, and rabbit homologs, which indicatesthat this enzyme is highly conserved in eukaryotic evolution.


Aston, K.I., et al. Hum. Reprod. 25(6):1383-1397(2010)Ryu, K.S., et al. BMB Rep 41(12):852-857(2008)Suryavathi, V., et al. J. Androl. 29(5):564-571(2008)Huang, I., et al. Asian J. Androl. 10(3):461-466(2008)Tsuji, Y., et al. Genes Cells 13(4):343-354(2008)

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$ 80.00
Cat# BP16790c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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