|Other Names||Dual specificity testis-specific protein kinase 1, Testicular protein kinase 1, TESK1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
This gene product is a serine/threonine protein kinasethat contains an N-terminal protein kinase domain and a C-terminalproline-rich domain. Its protein kinase domain is most closelyrelated to those of the LIM motif-containing protein kinases(LIMKs). The encoded protein can phosphorylate myelin basic proteinand histone in vitro. The testicular germ cell-specific expressionand developmental pattern of expression of the mouse gene suggeststhat this gene plays an important role at and after the meioticphase of spermatogenesis.
Davila, S., et al. Genes Immun. 11(3):232-238(2010)Johne, C., et al. Mol. Biol. Cell 19(4):1391-1403(2008)LaLonde, D.P., et al. J. Biol. Chem. 280(22):21680-21688(2005)Leeksma, O.C., et al. Eur. J. Biochem. 269(10):2546-2556(2002)Toshima, J.Y., et al. J. Biol. Chem. 276(46):43471-43481(2001)
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