ICA1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q05084 |
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Clone Names | 100623145 |
Gene ID | 3382 |
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Other Names | Islet cell autoantigen 1, 69 kDa islet cell autoantigen, ICA69, Islet cell autoantigen p69, ICAp69, p69, ICA1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ICA1 |
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Function | May play a role in neurotransmitter secretion. |
Cellular Location | Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. Note=Predominantly cytosolic. Also exists as a membrane-bound form which has been found associated with synaptic vesicles and also with the Golgi complex and immature secretory granules |
Tissue Location | Expressed abundantly in pancreas, heart and brain with low levels of expression in lung, kidney, liver and thyroid |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein with an arfaptin homologydomain that is found both in the cytosol and as membrane-bound formon the Golgi complex and immature secretory granules. This proteinis believed to be an autoantigen in insulin-dependent diabetesmellitus and primary Sjogren's syndrome. Alternatively splicedvariants which encode different protein isoforms have beendescribed; however, not all variants have been fully characterized.
References
Jin, Y., et al. Nat. Genet. 42(7):576-578(2010)Rose, J. Phd, et al. Mol. Med. (2010) In press :Buffa, L., et al. Eur. J. Cell Biol. 87(4):197-209(2008)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Gordon, T.P., et al. Lupus 13(6):483-484(2004)
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