|Other Names||Islet cell autoantigen 1, 69 kDa islet cell autoantigen, ICA69, Islet cell autoantigen p69, ICAp69, p69, ICA1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in neurotransmitter secretion.|
|Cellular Location||Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. Note=Predominantly cytosolic. Also exists as a membrane-bound form which has been found associated with synaptic vesicles and also with the Golgi complex and immature secretory granules|
|Tissue Location||Expressed abundantly in pancreas, heart and brain with low levels of expression in lung, kidney, liver and thyroid|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein with an arfaptin homologydomain that is found both in the cytosol and as membrane-bound formon the Golgi complex and immature secretory granules. This proteinis believed to be an autoantigen in insulin-dependent diabetesmellitus and primary Sjogren's syndrome. Alternatively splicedvariants which encode different protein isoforms have beendescribed; however, not all variants have been fully characterized.
Jin, Y., et al. Nat. Genet. 42(7):576-578(2010)Rose, J. Phd, et al. Mol. Med. (2010) In press :Buffa, L., et al. Eur. J. Cell Biol. 87(4):197-209(2008)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Gordon, T.P., et al. Lupus 13(6):483-484(2004)
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