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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   ICA1 Antibody (N-term) Blocking Peptide   

ICA1 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q05084
Clone Names 100623145
Peptide ID 100623145
Additional Information
Other Names Islet cell autoantigen 1, 69 kDa islet cell autoantigen, ICA69, Islet cell autoantigen p69, ICAp69, p69, ICA1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ICA1
Function May play a role in neurotransmitter secretion.
Cellular Location Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. Note=Predominantly cytosolic. Also exists as a membrane-bound form which has been found associated with synaptic vesicles and also with the Golgi complex and immature secretory granules
Tissue Location Expressed abundantly in pancreas, heart and brain with low levels of expression in lung, kidney, liver and thyroid EMBL; L01100; AAA02564.1; -; mRNA EMBL; L21181; AAA64927.1; -; mRNA EMBL; U26591; AAB19033.1; -; mRNA EMBL; U37183; AAC50935.1; -; mRNA EMBL; U71264; AAB94738.1; -; Genomic_DNA EMBL; U71251; AAB94738.1; JOINED; Genomic_DNA EMBL; U71252; AAB94738.1; JOINED; Genomic_DNA EMBL; U71253; AAB94738.1; JOINED; Genomic_DNA EMBL; U71255; AAB94738.1; JOINED; Genomic_DNA EMBL; U71256; AAB94738.1; JOINED; Genomic_DNA EMBL; U71257; AAB94738.1; JOINED; Genomic_DNA EMBL; U71258; AAB94738.1; JOINED; Genomic_DNA EMBL; U71259; AAB94738.1; JOINED; Genomic_DNA EMBL; U71260; AAB94738.1; JOINED; Genomic_DNA EMBL; U71261; AAB94738.1; JOINED; Genomic_DNA EMBL; U71262; AAB94738.1; JOINED; Genomic_DNA EMBL; U71263; AAB94738.1; JOINED; Genomic_DNA EMBL; EU416199; ACB47390.1; -; mRNA EMBL; AK292106; BAF84795.1; -; mRNA EMBL; AC006042; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; AC007009; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; CH471073; EAW93610.1; -; Genomic_DNA EMBL; CH471073; EAW93617.1; -; Genomic_DNA EMBL; BC008640; AAH08640.1; -; mRNA CCDS; CCDS34602.1; -. [Q05084-1] CCDS; CCDS64595.1; -. [Q05084-3] PIR; I55598; I55598 RefSeq; NP_001129492.1; NM_001136020.2. [Q05084-1] RefSeq; NP_001263407.1; NM_001276478.1. [Q05084-3] RefSeq; NP_004959.2; NM_004968.3. [Q05084-1] RefSeq; NP_071682.1; NM_022307.2. [Q05084-1] RefSeq; XP_005249792.1; XM_005249735.3 RefSeq; XP_011513647.1; XM_011515345.1 RefSeq; XP_011513648.1; XM_011515346.1 RefSeq; XP_011513649.1; XM_011515347.2. [Q05084-2] RefSeq; XP_011513650.1; XM_011515348.1. [Q05084-2] RefSeq; XP_011513651.1; XM_011515349.1. [Q05084-2] RefSeq; XP_016867606.1; XM_017012117.1 RefSeq; XP_016867607.1; XM_017012118.1 RefSeq; XP_016867608.1; XM_017012119.1 RefSeq; XP_016867609.1; XM_017012120.1 RefSeq; XP_016867610.1; XM_017012121.1 UniGene; Hs.487561; - ProteinModelPortal; Q05084; - SMR; Q05084; - BioGrid; 109609; 14 IntAct; Q05084; 13 STRING; 9606.ENSP00000379908; - iPTMnet; Q05084; - PhosphoSitePlus; Q05084; - BioMuta; ICA1; - DMDM; 20141584; - MaxQB; Q05084; - PaxDb; Q05084; - PeptideAtlas; Q05084; - PRIDE; Q05084; - ProteomicsDB; 58305; - DNASU; 3382; - Ensembl; ENST00000265577; ENSP00000265577; ENSG00000003147. [Q05084-3] Ensembl; ENST00000396675; ENSP00000379908; ENSG00000003147. [Q05084-1] Ensembl; ENST00000402384; ENSP00000385570; ENSG00000003147. [Q05084-1] Ensembl; ENST00000406470; ENSP00000385651; ENSG00000003147. [Q05084-1] Ensembl; ENST00000422063; ENSP00000403982; ENSG00000003147. [Q05084-2] GeneID; 3382; - KEGG; hsa:3382; - UCSC; uc003srm.4; human. [Q05084-1] CTD; 3382; - DisGeNET; 3382; - EuPathDB; HostDB:ENSG00000003147.17; - GeneCards; ICA1; - HGNC; HGNC:5343; ICA1 HPA; HPA017646; - HPA; HPA061452; - MIM; 147625; gene neXtProt; NX_Q05084; - OpenTargets; ENSG00000003147; - PharmGKB; PA29591; - eggNOG; KOG3891; Eukaryota eggNOG; ENOG410YJKW; LUCA GeneTree; ENSGT00390000005530; - HOGENOM; HOG000006612; - HOVERGEN; HBG061005; - InParanoid; Q05084; - KO; K19863; - OMA; HESFRGY; - OrthoDB; EOG091G0BDC; - PhylomeDB; Q05084; - TreeFam; TF317186; - ChiTaRS; ICA1; human GeneWiki; ICA1; - GenomeRNAi; 3382; - PRO; PR:Q05084; - Proteomes; UP000005640; Chromosome 7 Bgee; ENSG00000003147; - CleanEx; HS_ICA1; - ExpressionAtlas; Q05084; baseline and differential Genevisible; Q05084; HS GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW GO; GO:0005737; C:cytoplasm; TAS:ProtInc GO; GO:0005829; C:cytosol; IDA:HPA GO; GO:0000139; C:Golgi membrane; IDA:UniProtKB GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA GO; GO:0030667; C:secretory granule membrane; IDA:UniProtKB GO; GO:0030672; C:synaptic vesicle membrane; ISS:UniProtKB GO; GO:0019904; F:protein domain specific binding; IEA:InterPro GO; GO:0006836; P:neurotransmitter transport; IEA:UniProtKB-KW GO; GO:0050796; P:regulation of insulin secretion; IEA:InterPro Gene3D; 1.20.1270.60; -; 1 InterPro; IPR027267; AH/BAR_dom_sf InterPro; IPR010504; AH_dom InterPro; IPR030796; ICA1 InterPro; IPR024114; Islet_autoAg_Ica1/Ica1-like InterPro; IPR006723; Islet_autoAg_Ica1_C PANTHER; PTHR10164; PTHR10164; 1 PANTHER; PTHR10164:SF3; PTHR10164:SF3; 1 Pfam; PF06456; Arfaptin; 1 Pfam; PF04629; ICA69; 2 SMART; SM01015; Arfaptin; 1 SMART; SM01237; ICA69; 1 SUPFAM; SSF103657; SSF103657; 1 PROSITE; PS50870; AH; 1 1: Evidence at protein level; Alternative splicing; Cell junction; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Golgi apparatus; Membrane; Neurotransmitter transport; Reference proteome; Synapse; Transport CHAIN 1 483 Islet cell autoantigen 1 /FTId=PRO_0000084130 DOMAIN 51 254 AH. {ECO:0000255|PROSITE- ProRule:PRU00294} VAR_SEQ 7 7 Missing (in isoform 3) /FTId=VSP_055405 VAR_SEQ 301 301 Q -> QYLQNICLEMKANSDIKMLQKGKEGQQIGI (in isoform 2). {ECO:0000303|Ref.4} /FTId=VSP_047761 CONFLICT 29 29 K -> R (in Ref. 1; AAA02564) CONFLICT 83 83 R -> G (in Ref. 2; AAA64927) SEQUENCE 483 AA; 54645 MW; 1696F928EE7454C9 CRC64; MSGHKCSYPW DLQDRYAQDK SVVNKMQQKY WETKQAFIKA TGKKEDEHVV ASDADLDAKL ELFHSIQRTC LDLSKAIVLY QKRICFLSQE ENELGKFLRS QGFQDKTRAG KMMQATGKAL CFSSQQRLAL RNPLCRFHQE VETFRHRAIS DTWLTVNRME QCRTEYRGAL LWMKDVSQEL DPDLYKQMEK FRKVQTQVRL AKKNFDKLKM DVCQKVDLLG ASRCNLLSHM LATYQTTLLH FWEKTSHTMA AIHESFKGYQ PYEFTTLKSL QDPMKKLVEK EEKKKINQQE STDAAVQEPS QLISLEEENQ RKESSSFKTE DGKSILSALD KGSTHTACSG PIDELLDMKS EEGACLGPVA GTPEPEGADK DDLLLLSEIF NASSLEEGEF SKEWAAVFGD GQVKEPVPTM ALGEPDPKAQ TGSGFLPSQL LDQNMKDLQA SLQEPAKAAS DLTAWFSLFA DLDPLSNPDA VGKTDKEHEL LNA
Research Areas
Citations (0)

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Background

This gene encodes a protein with an arfaptin homologydomain that is found both in the cytosol and as membrane-bound formon the Golgi complex and immature secretory granules. This proteinis believed to be an autoantigen in insulin-dependent diabetesmellitus and primary Sjogren's syndrome. Alternatively splicedvariants which encode different protein isoforms have beendescribed; however, not all variants have been fully characterized.

References

Jin, Y., et al. Nat. Genet. 42(7):576-578(2010)Rose, J. Phd, et al. Mol. Med. (2010) In press :Buffa, L., et al. Eur. J. Cell Biol. 87(4):197-209(2008)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Gordon, T.P., et al. Lupus 13(6):483-484(2004)

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