|Other Names||High mobility group nucleosome-binding domain-containing protein 3, Thyroid receptor-interacting protein 7, TR-interacting protein 7, TRIP-7, HMGN3, TRIP7|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity).|
|Tissue Location||Expressed in kidney, lung, pancreas, testis, skeletal muscle, heart, thyroid gland, pituitary gland, prostate and uterus. Low expression in liver, spleen, placenta and ovaries|
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Thyroid hormone receptors are hormone-dependenttranscription factors that regulate expression of a variety ofspecific target genes. The protein encoded by this gene bindsthyroid hormone receptor beta, but only in the presence of thyroidhormone. The encoded protein, a member of the HMGN protein family,is thought to reduce the compactness of the chromatin fiber innucleosomes, thereby enhancing transcription from chromatintemplates. Two transcript variants encoding different isoforms havebeen found for this gene.
Ueda, T., et al. Mol. Cell. Biol. 29(19):5264-5276(2009)Wu, C., et al. Proteomics 7(11):1775-1785(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)Leong, P.W., et al. Virology 295(1):147-159(2002)
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