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HMGN3 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q15651 |
|---|---|
| Clone Names | 100603133 |
| Gene ID | 9324 |
|---|---|
| Other Names | High mobility group nucleosome-binding domain-containing protein 3, Thyroid receptor-interacting protein 7, TR-interacting protein 7, TRIP-7, HMGN3, TRIP7 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | HMGN3 |
|---|---|
| Synonyms | TRIP7 |
| Function | Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity). |
| Cellular Location | Nucleus. |
| Tissue Location | Expressed in kidney, lung, pancreas, testis, skeletal muscle, heart, thyroid gland, pituitary gland, prostate and uterus. Low expression in liver, spleen, placenta and ovaries |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Thyroid hormone receptors are hormone-dependenttranscription factors that regulate expression of a variety ofspecific target genes. The protein encoded by this gene bindsthyroid hormone receptor beta, but only in the presence of thyroidhormone. The encoded protein, a member of the HMGN protein family,is thought to reduce the compactness of the chromatin fiber innucleosomes, thereby enhancing transcription from chromatintemplates. Two transcript variants encoding different isoforms havebeen found for this gene.
References
Ueda, T., et al. Mol. Cell. Biol. 29(19):5264-5276(2009)Wu, C., et al. Proteomics 7(11):1775-1785(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)Leong, P.W., et al. Virology 295(1):147-159(2002)
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