|Other Names||ATP synthase subunit delta, mitochondrial, F-ATPase delta subunit, ATP5D|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.|
|Cellular Location||Mitochondrion. Mitochondrion inner membrane.|
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This gene encodes a subunit of mitochondrial ATP synthase.Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing anelectrochemical gradient of protons across the inner membraneduring oxidative phosphorylation. ATP synthase is composed of twolinked multi-subunit complexes: the soluble catalytic core, F1, andthe membrane-spanning component, Fo, comprising the proton channel.The catalytic portion of mitochondrial ATP synthase consists of 5different subunits (alpha, beta, gamma, delta, and epsilon)assembled with a stoichiometry of 3 alpha, 3 beta, and a singlerepresentative of the other 3. The proton channel consists of threemain subunits (a, b, c). This gene encodes the delta subunit of thecatalytic core. Alternatively spliced transcript variants encodingthe same isoform have been identified.
Grimwood, J., et al. Nature 428(6982):529-535(2004)Itoh, H., et al. Nature 427(6973):465-468(2004)Cross, R.L. Nature 427(6973):407-408(2004)Hong, S., et al. J. Bioenerg. Biomembr. 35(2):95-120(2003)Medeiros, D.M., et al. J. Bioenerg. Biomembr. 34(5):389-395(2002)
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