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PBXIP1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96AQ6 |
|---|---|
| Clone Names | 100406155 |
| Gene ID | 57326 |
|---|---|
| Other Names | Pre-B-cell leukemia transcription factor-interacting protein 1, Hematopoietic PBX-interacting protein, PBXIP1, HPIP |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PBXIP1 |
|---|---|
| Synonyms | HPIP |
| Function | Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor- alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling. |
| Cellular Location | Cytoplasm, cytoskeleton. Nucleus Note=Shuttles between the nucleus and the cytosol (PubMed:12360403) Mainly localized in the cytoplasm, associated with microtubules (PubMed:10825160, PubMed:12360403). Detected in small amounts in the nucleus (PubMed:10825160) |
| Tissue Location | Expressed in early hematopoietic precursors. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling.
References
Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)Olsen, J.V., et al. Cell 127(3):635-648(2006)Lim, J., et al. Cell 125(4):801-814(2006)Abramovich, C., et al. Oncogene 21(44):6766-6771(2002)Abramovich, C., et al. J. Biol. Chem. 275(34):26172-26177(2000)
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