|Other Names||Short transient receptor potential channel 1, TrpC1, Transient receptor protein 1, TRP-1, TRPC1, TRP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Seems to be ubiquitous.|
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Provided below are standard protocols that you may find useful for product applications.
TRPC1 belongs to the transient receptor potential (TRP)superfamily of cation channels. TRP cation channels are involved indiverse physiologic processes, including receptor- andstore-operated Ca(2+) entry, mineral absorption, and cell death.They also function as sensors for pain, heat, cold, sound, stretch,and osmotic changes (Zhang et al., 2009 [PubMed19193631]).
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Bomben, V.C., et al. Glia 58(10):1145-1156(2010)Lu, M., et al. J. Mol. Endocrinol. 44(5):285-294(2010)Gonzalez-Cobos, J.C., et al. Front. Biosci. 15, 1023-1039 (2010) :Ingueneau, C., et al. J. Cell. Mol. Med. 13 (8B), 1620-1631 (2009) :
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