|Other Names||RecQ-mediated genome instability protein 1, BLM-associated protein of 75 kDa, BLAP75, FAAP75, RMI1, C9orf76|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.|
|Cellular Location||Nucleus. Note=Forms foci in response to DNA damage|
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Provided below are standard protocols that you may find useful for product applications.
RMI1 is a component of protein complexes that limit DNAcrossover formation via the dissolution of double Hollidayjunctions (Raynard et al., 2006 [PubMed 16595695]).[supplied byOMIM].
Yang, J., et al. J. Biol. Chem. 285(28):21426-21436(2010)Frank, B., et al. Carcinogenesis 31(3):442-445(2010)Barber, M.J., et al. PLoS ONE 5 (3), E9763 (2010) :Luedeke, M., et al. Cancer Epidemiol. Biomarkers Prev. 18(11):3030-3035(2009)Broberg, K., et al. BMC Cancer 9, 140 (2009) :
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