|Other Names||Ras GTPase-activating-like protein IQGAP1, p195, IQGAP1, KIAA0051|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth.|
|Cellular Location||Cell membrane.|
|Tissue Location||Expressed in the placenta, lung, and kidney. A lower level expression is seen in the heart, liver, skeletal muscle and pancreas|
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This gene encodes a member of the IQGAP family. Theprotein contains four IQ domains, one calponin homology domain, oneRas-GAP domain and one WW domain. It interacts with components ofthe cytoskeleton, with cell adhesion molecules, and with severalsignaling molecules to regulate cell morphology and motility.Expression of the protein is upregulated by gene amplification intwo gastric cancer cell lines.
Hayashi, H., et al. Int. J. Cancer 126(11):2563-2574(2010)Liang, S., et al. Proteomics 10(7):1474-1483(2010)Nakhaei-Nejad, M., et al. Eur. J. Immunol. 40(1):204-213(2010)Wang, J.B., et al. J. Cell. Sci. 122 (PT 12), 2024-2033 (2009) :Usatyuk, P.V., et al. J. Biol. Chem. 284(22):15339-15352(2009)
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