UBE2H Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P62256 |
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Clone Names | 100617183 |
Gene ID | 7328 |
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Other Names | Ubiquitin-conjugating enzyme E2 H, UbcH2, Ubiquitin carrier protein H, Ubiquitin-conjugating enzyme E2-20K, Ubiquitin-protein ligase H, UBE2H |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | UBE2H |
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Function | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:8132613, PubMed:17588522, PubMed:20061386). E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination (PubMed:20061386). Capable, in vitro, to ubiquitinate histone H2A (PubMed:8132613). |
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Provided below are standard protocols that you may find useful for product applications.
Background
The modification of proteins with ubiquitin is animportant cellular mechanism for targeting abnormal or short-livedproteins for degradation. Ubiquitination involves at least threeclasses of enzymes: ubiquitin-activating enzymes, or E1s,ubiquitin-conjugating enzymes, or E2s, and ubiquitin-proteinligases, or E3s. This gene encodes a member of the E2ubiquitin-conjugating enzyme family. The encoded protein sequenceis 100% identical to the mouse homolog and 98% identical to thefrog and zebrafish homologs. Two alternatively spliced transcriptvariants have been found for this gene and they encode distinctisoforms.
References
Lausen, J., et al. J. Biol. Chem. 285(8):5338-5346(2010)Martin, I., et al. Amyotroph Lateral Scler 10 (5-6), 432-435 (2009) :de Krom, M., et al. Biol. Psychiatry 65(7):625-630(2009)Martin, I., et al. Amyotroph Lateral Scler, 1-4 (2008) In press :Kim, H.J., et al. Immunol. Lett. 95(2):155-159(2004)
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