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UBE2H Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P62256
Clone Names 100617183
Additional Information
Gene ID 7328
Other Names Ubiquitin-conjugating enzyme E2 H, UbcH2, Ubiquitin carrier protein H, Ubiquitin-conjugating enzyme E2-20K, Ubiquitin-protein ligase H, UBE2H
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name UBE2H
Function Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:8132613, PubMed:17588522, PubMed:20061386). E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination (PubMed:20061386). Capable, in vitro, to ubiquitinate histone H2A (PubMed:8132613).
Research Areas
Citations (0)
citation

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Background

The modification of proteins with ubiquitin is animportant cellular mechanism for targeting abnormal or short-livedproteins for degradation. Ubiquitination involves at least threeclasses of enzymes: ubiquitin-activating enzymes, or E1s,ubiquitin-conjugating enzymes, or E2s, and ubiquitin-proteinligases, or E3s. This gene encodes a member of the E2ubiquitin-conjugating enzyme family. The encoded protein sequenceis 100% identical to the mouse homolog and 98% identical to thefrog and zebrafish homologs. Two alternatively spliced transcriptvariants have been found for this gene and they encode distinctisoforms.

References

Lausen, J., et al. J. Biol. Chem. 285(8):5338-5346(2010)Martin, I., et al. Amyotroph Lateral Scler 10 (5-6), 432-435 (2009) :de Krom, M., et al. Biol. Psychiatry 65(7):625-630(2009)Martin, I., et al. Amyotroph Lateral Scler, 1-4 (2008) In press :Kim, H.J., et al. Immunol. Lett. 95(2):155-159(2004)

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$ 277.78
Cat# BP16924c
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Availability: 2 weeks
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