|Other Names||Ubiquitin-conjugating enzyme E2 H, UbcH2, Ubiquitin carrier protein H, Ubiquitin-conjugating enzyme E2-20K, Ubiquitin-protein ligase H, UBE2H|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A.|
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Provided below are standard protocols that you may find useful for product applications.
The modification of proteins with ubiquitin is animportant cellular mechanism for targeting abnormal or short-livedproteins for degradation. Ubiquitination involves at least threeclasses of enzymes: ubiquitin-activating enzymes, or E1s,ubiquitin-conjugating enzymes, or E2s, and ubiquitin-proteinligases, or E3s. This gene encodes a member of the E2ubiquitin-conjugating enzyme family. The encoded protein sequenceis 100% identical to the mouse homolog and 98% identical to thefrog and zebrafish homologs. Two alternatively spliced transcriptvariants have been found for this gene and they encode distinctisoforms.
Lausen, J., et al. J. Biol. Chem. 285(8):5338-5346(2010)Martin, I., et al. Amyotroph Lateral Scler 10 (5-6), 432-435 (2009) :de Krom, M., et al. Biol. Psychiatry 65(7):625-630(2009)Martin, I., et al. Amyotroph Lateral Scler, 1-4 (2008) In press :Kim, H.J., et al. Immunol. Lett. 95(2):155-159(2004)
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