|Other Names||Sodium-dependent dopamine transporter, DA transporter, DAT, Solute carrier family 6 member 3, SLC6A3, DAT1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.|
|Cellular Location||Cell membrane; Multi- pass membrane protein|
|Tissue Location||Highly expressed in substantia nigra.|
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This gene encodes a dopamine transporter which is a memberof the sodium- and chloride-dependent neurotransmitter transporterfamily. The 3' UTR of this gene contains a 40 bp tandem repeat,referred to as a variable number tandem repeat or VNTR, which canbe present in 3 to 11 copies. Variation in the number of repeats isassociated with idiopathic epilepsy, attention-deficithyperactivity disorder, dependence on alcohol and cocaine,susceptibility to Parkinson disease and protection against nicotinedependence.
Simon, J.R., et al. Behav. Brain Res. 216(1):452-457(2011)Paloyelis, Y., et al. Neuropsychopharmacology 35(12):2414-2426(2010)Shang, C.Y., et al. Prog. Neuropsychopharmacol. Biol. Psychiatry (2010) In press :Jijun, L., et al. Neurol India 58(4):523-529(2010)Torres, G.E., et al. J. Biol. Chem. 278(4):2731-2739(2003)
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