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SLC6A3 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q01959 |
|---|---|
| Clone Names | 100430239 |
| Gene ID | 6531 |
|---|---|
| Other Names | Sodium-dependent dopamine transporter, DA transporter, DAT, Solute carrier family 6 member 3, SLC6A3, DAT1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLC6A3 |
|---|---|
| Synonyms | DAT1 |
| Function | Mediates sodium- and chloride-dependent transport of dopamine (PubMed:1406597, PubMed:8302271, PubMed:10375632, PubMed:11093780, PubMed:15505207, PubMed:19478460). Also mediates sodium- and chloride- dependent transport of norepinephrine (also known as noradrenaline) (By similarity). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Cell projection, neuron projection {ECO:0000250|UniProtKB:P23977}. Cell projection, axon. Note=Localizes to neurite tips in neuronal cells (By similarity). Colocalizes with SEPTIN4 at axon terminals, especially at the varicosities (By similarity) {ECO:0000250|UniProtKB:P23977, ECO:0000250|UniProtKB:Q61327} |
| Tissue Location | Highly expressed in substantia nigra (PubMed:7637582). Expressed in axonal varicosities in dopaminergic nerve terminals (at protein level) (PubMed:17296554). Expressed in the striatum (at protein level) (PubMed:17296554) |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a dopamine transporter which is a memberof the sodium- and chloride-dependent neurotransmitter transporterfamily. The 3' UTR of this gene contains a 40 bp tandem repeat,referred to as a variable number tandem repeat or VNTR, which canbe present in 3 to 11 copies. Variation in the number of repeats isassociated with idiopathic epilepsy, attention-deficithyperactivity disorder, dependence on alcohol and cocaine,susceptibility to Parkinson disease and protection against nicotinedependence.
References
Simon, J.R., et al. Behav. Brain Res. 216(1):452-457(2011)Paloyelis, Y., et al. Neuropsychopharmacology 35(12):2414-2426(2010)Shang, C.Y., et al. Prog. Neuropsychopharmacol. Biol. Psychiatry (2010) In press :Jijun, L., et al. Neurol India 58(4):523-529(2010)Torres, G.E., et al. J. Biol. Chem. 278(4):2731-2739(2003)
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