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CPNE6 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O95741
Clone Names 110617033
Peptide ID 110617033
Additional Information
Gene ID 9362
Other Names Copine-6, Copine VI, Neuronal-copine, N-copine, CPNE6
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CPNE6 (HGNC:2319)
Function Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:Q9Z140}. Cell membrane {ECO:0000250|UniProtKB:Q9Z140}. Endosome {ECO:0000250|UniProtKB:Q9Z140}. Cytoplasmic vesicle, clathrin- coated vesicle {ECO:0000250|UniProtKB:Q9Z140}. Perikaryon {ECO:0000250|UniProtKB:Q9Z140}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9Z140}. Note=Mainly cytoplasmic in absence of calcium. Associated predominantly with membranes in presence of calcium. Translocates to the cell membrane in a calcium-dependent manner. Colocalized with transferrin in intracellular clathrin- coated membrane vesicles in a calcium-dependent manner {ECO:0000250|UniProtKB:Q9Z140}
Tissue Location Widely expressed in the brain (PubMed:9645480, PubMed:10403379, PubMed:12949241). Expressed weakly in the kidney, liver and fetal heart (PubMed:12949241). Expressed in melanocytes (PubMed:23999003).
Research Areas
Citations (0)

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Background

This gene encodes a brain-specific member of the copinefamily, which is composed of calcium-dependent membrane-bindingproteins. The gene product contains two N-terminal C2 domains, andone von Willebrand factor A domain. It may have a role in synapticplasticity.

References

Caudell, E.G., et al. Biochemistry 39(42):13034-13043(2000)Nakayama, T., et al. FEBS Lett. 453 (1-2), 77-80 (1999) :Nakayama, T., et al. J. Neurochem. 72(1):373-379(1999)Nakayama, T., et al. FEBS Lett. 428 (1-2), 80-84 (1998) :

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$ 80.00
Cat# BP16941a
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