|Other Names||Membrane-spanning 4-domains subfamily A member 7, CD20 antigen-like 4, CD20/FC-epsilon-RI-beta family member 4, Four-span transmembrane protein 2, MS4A7, 4SPAN2, CD20L4, CFFM4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||4SPAN2, CD20L4, CFFM4|
|Function||May be involved in signal transduction as a component of a multimeric receptor complex.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Ubiquitous expression in normal tissues. Expression is more elevated in adult liver, lung, spleen, and heart than in their fetal counterparts, and is higher in normal tissues than in the cancerous tissue or cell lines. Low levels of expression were detected in the promonocytic stage, whereas high levels of expression were detected in mature monocytes|
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This gene encodes a member of the membrane-spanning 4Agene family, members of which are characterized by commonstructural features and similar intron/exon splice boundaries anddisplay unique expression patterns in hematopoietic cells andnonlymphoid tissues. This family member is associated with maturecellular function in the monocytic lineage, and it may be acomponent of a receptor complex involved in signal transduction.This gene is localized to 11q12, in a cluster of other familymembers. At least four alternatively spliced transcript variantsencoding two distinct isoforms have been observed. [provided byRefSeq].
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Gingras, M.C., et al. Immunogenetics 53(6):468-476(2001)Liang, Y., et al. Immunogenetics 53(5):357-368(2001)Liang, Y., et al. Genomics 72(2):119-127(2001)Ishibashi, K., et al. Gene 264(1):87-93(2001)
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