|Other Names||Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1, Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit, Ribophorin I, RPN-I, Ribophorin-1, RPN1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type I membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV|
|Tissue Location||Expressed in all tissues tested.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a type I integral membrane protein foundonly in the rough endoplasmic reticulum. The encoded protein ispart of an N-oligosaccharyl transferase complex that links highmannose oligosaccharides to asparagine residues found in theAsn-X-Ser/Thr consensus motif of nascent polypeptide chains. Thisprotein forms part of the regulatory subunit of the 26S proteasomeand may mediate binding of ubiquitin-like domains to thisproteasome.
Ruiz-Canada, C., et al. Cell 136(2):272-283(2009)Wang, L., et al. Cancer Epidemiol. Biomarkers Prev. 17(12):3558-3566(2008)Wilson, C.M., et al. Proc. Natl. Acad. Sci. U.S.A. 105(28):9534-9539(2008)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Chi, A., et al. J. Proteome Res. 5(11):3135-3144(2006)
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