|Other Names||Macrophage scavenger receptor types I and II, Macrophage acetylated LDL receptor I and II, Scavenger receptor class A member 1, CD204, MSR1, SCARA1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL) (PubMed:2251254). Isoform III does not internalize acetylated LDL (PubMed:9548586).|
|Cellular Location||Membrane; Single-pass type II membrane protein|
|Tissue Location||Isoform I, isoform II and isoform III are expressed in monocyte-derived macrophages. Isoform I and isoform II are expressed in the liver, placenta and brain|
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This gene encodes the class A macrophage scavengerreceptors, which include three different types (1, 2, 3) generatedby alternative splicing of this gene. These receptors or isoformsare macrophage-specific trimeric integral membrane glycoproteinsand have been implicated in many macrophage-associatedphysiological and pathological processes including atherosclerosis,Alzheimer's disease, and host defense. The isoforms type 1 and type2 are functional receptors and are able to mediate the endocytosisof modified low density lipoproteins (LDLs). The isoform type 3does not internalize modified LDL (acetyl-LDL) despite having thedomain shown to mediate this function in the types 1 and 2isoforms. It has an altered intracellular processing and is trappedwithin the endoplasmic reticulum, making it unable to performendocytosis. The isoform type 3 can inhibit the function ofisoforms type 1 and type 2 when co-expressed, indicating a dominantnegative effect and suggesting a mechanism for regulation ofscavenger receptor activity in macrophages.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Wang, Y., et al. J. Hum. Genet. 55(8):490-494(2010)Voruganti, V.S., et al. Am. J. Clin. Nutr. 91(6):1574-1583(2010)Nonomura, N., et al. Cancer Sci. 101(6):1570-1573(2010)Seizer, P., et al. Semin. Thromb. Hemost. 36(2):157-162(2010)
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