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MSR1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P21757
Clone Names 100430276
Peptide ID 100430276
Additional Information
Gene ID 4481
Other Names Macrophage scavenger receptor types I and II, Macrophage acetylated LDL receptor I and II, Scavenger receptor class A member 1, CD204, MSR1, SCARA1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MSR1
Synonyms SCARA1
Function Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). Isoform III does not internalize acetylated LDL.
Cellular Location Membrane; Single-pass type II membrane protein
Tissue Location Isoform I, isoform II and isoform III are expressed in monocyte-derived macrophages
Research Areas
Citations (0)

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This gene encodes the class A macrophage scavengerreceptors, which include three different types (1, 2, 3) generatedby alternative splicing of this gene. These receptors or isoformsare macrophage-specific trimeric integral membrane glycoproteinsand have been implicated in many macrophage-associatedphysiological and pathological processes including atherosclerosis,Alzheimer's disease, and host defense. The isoforms type 1 and type2 are functional receptors and are able to mediate the endocytosisof modified low density lipoproteins (LDLs). The isoform type 3does not internalize modified LDL (acetyl-LDL) despite having thedomain shown to mediate this function in the types 1 and 2isoforms. It has an altered intracellular processing and is trappedwithin the endoplasmic reticulum, making it unable to performendocytosis. The isoform type 3 can inhibit the function ofisoforms type 1 and type 2 when co-expressed, indicating a dominantnegative effect and suggesting a mechanism for regulation ofscavenger receptor activity in macrophages.


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Wang, Y., et al. J. Hum. Genet. 55(8):490-494(2010)Voruganti, V.S., et al. Am. J. Clin. Nutr. 91(6):1574-1583(2010)Nonomura, N., et al. Cancer Sci. 101(6):1570-1573(2010)Seizer, P., et al. Semin. Thromb. Hemost. 36(2):157-162(2010)

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$ 80.00
Cat# BP17001b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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