|Other Names||Antileukoproteinase, ALP, BLPI, HUSI-1, Mucus proteinase inhibitor, MPI, Protease inhibitor WAP4, Secretory leukocyte protease inhibitor, Seminal proteinase inhibitor, WAP four-disulfide core domain protein 4, SLPI, WAP4, WFDC4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. May prevent elastase-mediated damage to oral and possibly other mucosal tissues.|
|Tissue Location||Mucous fluids.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a secreted inhibitor which protectsepithelial tissues from serine proteases. It is found in varioussecretions including seminal plasma, cervical mucus, and bronchialsecretions, and has affinity for trypsin, leukocyte elastase, andcathepsin G. Its inhibitory effect contributes to the immuneresponse by protecting epithelial surfaces from attack byendogenous proteolytic enzymes; the protein is also thought to havebroad-spectrum anti-biotic activity.
Chotirmall, S.H., et al. Am. J. Respir. Crit. Care Med. 182(1):62-72(2010)Rasool, N., et al. Clin. Cancer Res. 16(2):600-609(2010)Ghasemlou, N., et al. Brain 133 (PT 1), 126-138 (2010) :Taggart, C.C., et al. J. Biol. Chem. 276(36):33345-33352(2001)Ohlsson, K., et al. J. Androl. 16(1):64-74(1995)
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