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SLPI Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P03973 |
|---|---|
| Clone Names | 100507216 |
| Gene ID | 6590 |
|---|---|
| Other Names | Antileukoproteinase, ALP, BLPI, HUSI-1, Mucus proteinase inhibitor, MPI, Protease inhibitor WAP4, Secretory leukocyte protease inhibitor, Seminal proteinase inhibitor, WAP four-disulfide core domain protein 4, SLPI, WAP4, WFDC4 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLPI |
|---|---|
| Synonyms | WAP4, WFDC4 |
| Function | Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G (PubMed:3533531, PubMed:3462719, PubMed:2039600, PubMed:2110563, PubMed:10702419, PubMed:24121345). Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS) (By similarity). Plays a role in regulating the activation of NF-kappa- B and inflammatory responses (PubMed:10702419, PubMed:24352879). Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for normal resistance to infection by L.major. Required for normal wound healing, probably by preventing tissue damage by limiting protease activity (By similarity). Together with ELANE, required for normal differentiation and proliferation of bone marrow myeloid cells (PubMed:24352879). |
| Cellular Location | Secreted |
| Tissue Location | Detected in blood plasma (PubMed:24352879). Detected in bone marrow myeloid cells (PubMed:24352879). Detected in airway sputum (PubMed:2039600). Detected in parotid gland secretions (PubMed:3462719). Detected in seminal plasma (at protein level) (PubMed:3485543). Detected in uterus cervix (PubMed:3533531) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a secreted inhibitor which protectsepithelial tissues from serine proteases. It is found in varioussecretions including seminal plasma, cervical mucus, and bronchialsecretions, and has affinity for trypsin, leukocyte elastase, andcathepsin G. Its inhibitory effect contributes to the immuneresponse by protecting epithelial surfaces from attack byendogenous proteolytic enzymes; the protein is also thought to havebroad-spectrum anti-biotic activity.
References
Chotirmall, S.H., et al. Am. J. Respir. Crit. Care Med. 182(1):62-72(2010)Rasool, N., et al. Clin. Cancer Res. 16(2):600-609(2010)Ghasemlou, N., et al. Brain 133 (PT 1), 126-138 (2010) :Taggart, C.C., et al. J. Biol. Chem. 276(36):33345-33352(2001)Ohlsson, K., et al. J. Androl. 16(1):64-74(1995)
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