|Other Names||Antileukoproteinase, ALP, BLPI, HUSI-1, Mucus proteinase inhibitor, MPI, Protease inhibitor WAP4, Secretory leukocyte protease inhibitor, Seminal proteinase inhibitor, WAP four-disulfide core domain protein 4, SLPI, WAP4, WFDC4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G (PubMed:3533531, PubMed:3462719, PubMed:2039600, PubMed:2110563, PubMed:10702419, PubMed:24121345). Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS) (By similarity). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses (PubMed:10702419, PubMed:24352879). Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for normal resistance to infection by L.major. Required for normal wound healing, probably by preventing tissue damage by limiting protease activity (By similarity). Together with ELANE, required for normal differentiation and proliferation of bone marrow myeloid cells (PubMed:24352879).|
|Tissue Location||Detected in blood plasma (PubMed:24352879). Detected in bone marrow myeloid cells (PubMed:24352879). Detected in airway sputum (PubMed:2039600). Detected in parotid gland secretions (PubMed:3462719). Detected in seminal plasma (at protein level) (PubMed:3485543). Detected in uterus cervix (PubMed:3533531).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a secreted inhibitor which protectsepithelial tissues from serine proteases. It is found in varioussecretions including seminal plasma, cervical mucus, and bronchialsecretions, and has affinity for trypsin, leukocyte elastase, andcathepsin G. Its inhibitory effect contributes to the immuneresponse by protecting epithelial surfaces from attack byendogenous proteolytic enzymes; the protein is also thought to havebroad-spectrum anti-biotic activity.
Chotirmall, S.H., et al. Am. J. Respir. Crit. Care Med. 182(1):62-72(2010)Rasool, N., et al. Clin. Cancer Res. 16(2):600-609(2010)Ghasemlou, N., et al. Brain 133 (PT 1), 126-138 (2010) :Taggart, C.C., et al. J. Biol. Chem. 276(36):33345-33352(2001)Ohlsson, K., et al. J. Androl. 16(1):64-74(1995)
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