|Other Names||Alpha-1A adrenergic receptor, Alpha-1A adrenoreceptor, Alpha-1A adrenoceptor, Alpha-1C adrenergic receptor, Alpha-adrenergic receptor 1c, ADRA1A, ADRA1C|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.|
|Cellular Location||Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes|
|Tissue Location||Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethral and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart|
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Alpha-1-adrenergic receptors (alpha-1-ARs) are members ofthe G protein-coupled receptor superfamily. They activate mitogenicresponses and regulate growth and proliferation of many cells.There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all ofwhich signal through the Gq/11 family of G-proteins and differentsubtypes show different patterns of activation. This gene encodesalpha-1A-adrenergic receptor. Alternative splicing of this genegenerates four transcript variants, which encode four differentisoforms with distinct C-termini but having similar ligand bindingproperties.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Gao, Y., et al. Ophthalmology (2010) In press :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Sorrentino, S., et al. Auton Neurosci 155 (1-2), 98-103 (2010) :Herlyn, P., et al. Clin J Pain 26(3):175-181(2010)
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