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ADRA1A Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P35348 |
|---|---|
| Clone Names | 100507220 |
| Gene ID | 148 |
|---|---|
| Other Names | Alpha-1A adrenergic receptor, Alpha-1A adrenoreceptor, Alpha-1A adrenoceptor, Alpha-1C adrenergic receptor, Alpha-adrenergic receptor 1c, ADRA1A, ADRA1C |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ADRA1A |
|---|---|
| Synonyms | ADRA1C |
| Function | This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. |
| Cellular Location | Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm Membrane, caveola. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK- mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes |
| Tissue Location | Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethral and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Alpha-1-adrenergic receptors (alpha-1-ARs) are members ofthe G protein-coupled receptor superfamily. They activate mitogenicresponses and regulate growth and proliferation of many cells.There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all ofwhich signal through the Gq/11 family of G-proteins and differentsubtypes show different patterns of activation. This gene encodesalpha-1A-adrenergic receptor. Alternative splicing of this genegenerates four transcript variants, which encode four differentisoforms with distinct C-termini but having similar ligand bindingproperties.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Gao, Y., et al. Ophthalmology (2010) In press :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Sorrentino, S., et al. Auton Neurosci 155 (1-2), 98-103 (2010) :Herlyn, P., et al. Clin J Pain 26(3):175-181(2010)
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