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ADRA1A Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P35348
Clone Names 100507220
Peptide ID 100507220
Additional Information
Gene ID 148
Other Names Alpha-1A adrenergic receptor, Alpha-1A adrenoreceptor, Alpha-1A adrenoceptor, Alpha-1C adrenergic receptor, Alpha-adrenergic receptor 1c, ADRA1A, ADRA1C
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms ADRA1C
Function This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
Cellular Location Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes
Tissue Location Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethral and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart
Research Areas
Citations (0)

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Alpha-1-adrenergic receptors (alpha-1-ARs) are members ofthe G protein-coupled receptor superfamily. They activate mitogenicresponses and regulate growth and proliferation of many cells.There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all ofwhich signal through the Gq/11 family of G-proteins and differentsubtypes show different patterns of activation. This gene encodesalpha-1A-adrenergic receptor. Alternative splicing of this genegenerates four transcript variants, which encode four differentisoforms with distinct C-termini but having similar ligand bindingproperties.


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Gao, Y., et al. Ophthalmology (2010) In press :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Sorrentino, S., et al. Auton Neurosci 155 (1-2), 98-103 (2010) :Herlyn, P., et al. Clin J Pain 26(3):175-181(2010)

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$ 80.00
Cat# BP17016b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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