|Other Names||Troponin T, fast skeletal muscle, TnTf, Beta-TnTF, Fast skeletal muscle troponin T, fTnT, TNNT3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.|
|Tissue Location||In fetal and adult fast skeletal muscles, with a higher level expression in fetal than in adult muscle|
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The binding of Ca(2+) to the trimeric troponin complexinitiates the process of muscle contraction. Increased Ca(2+)concentrations produce a conformational change in the troponincomplex that is transmitted to tropomyosin dimers situated alongactin filaments. The altered conformation permits increasedinteraction between a myosin head and an actin filament which,ultimately, produces a muscle contraction. The troponin complex hasprotein subunits C, I, and T. Subunit C binds Ca(2+) and subunit Ibinds to actin and inhibits actin-myosin interaction. Subunit Tbinds the troponin complex to the tropomyosin complex and is alsorequired for Ca(2+)-mediated activation of actomyosin ATPaseactivity. There are 3 different troponin T genes that encodetissue-specific isoforms of subunit T for fast skeletal-, slowskeletal-, and cardiac-muscle. This gene encodes fast skeletaltroponin T protein; also known as troponin T type 3. Alternativesplicing results in multiple transcript variants encodingadditional distinct troponin T type 3 isoforms. A developmentallyregulated switch between fetal/neonatal and adult troponin T type 3isoforms occurs. Additional splice variants have been described buttheir biological validity has not been established. Mutations inthis gene may cause distal arthrogryposis multiplex congenita type2B (DA2B).
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Turnbull, C., et al. Nat. Genet. 42(6):504-507(2010)Vihola, A., et al. Acta Neuropathol. 119(4):465-479(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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