|Other Names||Troponin T, fast skeletal muscle, TnTf, Beta-TnTF, Fast skeletal muscle troponin T, fTnT, TNNT3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.|
|Tissue Location||In fetal and adult fast skeletal muscles, with a higher level expression in fetal than in adult muscle|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
The binding of Ca(2+) to the trimeric troponin complexinitiates the process of muscle contraction. Increased Ca(2+)concentrations produce a conformational change in the troponincomplex that is transmitted to tropomyosin dimers situated alongactin filaments. The altered conformation permits increasedinteraction between a myosin head and an actin filament which,ultimately, produces a muscle contraction. The troponin complex hasprotein subunits C, I, and T. Subunit C binds Ca(2+) and subunit Ibinds to actin and inhibits actin-myosin interaction. Subunit Tbinds the troponin complex to the tropomyosin complex and is alsorequired for Ca(2+)-mediated activation of actomyosin ATPaseactivity. There are 3 different troponin T genes that encodetissue-specific isoforms of subunit T for fast skeletal-, slowskeletal-, and cardiac-muscle. This gene encodes fast skeletaltroponin T protein; also known as troponin T type 3. Alternativesplicing results in multiple transcript variants encodingadditional distinct troponin T type 3 isoforms. A developmentallyregulated switch between fetal/neonatal and adult troponin T type 3isoforms occurs. Additional splice variants have been described buttheir biological validity has not been established. Mutations inthis gene may cause distal arthrogryposis multiplex congenita type2B (DA2B).
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Turnbull, C., et al. Nat. Genet. 42(6):504-507(2010)Vihola, A., et al. Acta Neuropathol. 119(4):465-479(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.