|Other Names||LIM domain-binding protein 3, Protein cypher, Z-band alternatively spliced PDZ-motif protein, LDB3 (HGNC:15710)|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton.|
|Cellular Location||Cytoplasm, perinuclear region. Cell projection, pseudopodium. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Note=Localized to the cytoplasm around nuclei and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells Colocalizes with ACTN2 at the Z-lines|
|Tissue Location||Expressed primarily in skeletal muscle and to a lesser extent in heart. Also detected in brain and placenta|
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This gene encodes a PDZ domain-containing protein. PDZmotifs are modular protein-protein interaction domains consistingof 80-120 amino acid residues. PDZ domain-containing proteinsinteract with each other in cytoskeletal assembly or with otherproteins involved in targeting and clustering of membrane proteins.The protein encoded by this gene interacts with alpha-actinin-2through its N-terminal PDZ domain and with protein kinase C via itsC-terminal LIM domains. The LIM domain is a cysteine-rich motifdefined by 50-60 amino acids containing two zinc-binding modules.This protein also interacts with all three members of the myozeninfamily. Mutations in this gene have been associated withmyofibrillar myopathy and dilated cardiomyopathy. Alternativelyspliced transcript variants encoding different isoforms have beenidentified; all isoforms have N-terminal PDZ domains while onlylonger isoforms (1, 2 and 5) have C-terminal LIM domains. [providedby RefSeq].
Lechuga, S., et al. Exp. Cell Res. 316(19):3124-3139(2010)Zimmerman, R.S., et al. Genet. Med. 12(5):268-278(2010)Vihola, A., et al. Acta Neuropathol. 119(4):465-479(2010)Rampersaud, E., et al. Ann. Hum. Genet. 74(2):110-116(2010)Aurino, S., et al. Acta Myol 27, 90-97 (2008) :
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