|Other Names||Tyrosine-protein phosphatase non-receptor type 5, Neural-specific protein-tyrosine phosphatase, Striatum-enriched protein-tyrosine phosphatase, STEP, PTPN5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
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STEP (Protein-tyrosine phosphatase striatum-enriched) is a neural-specific protein-tyrosine phosphatase. It is also known as PTPN5 (tyrosine-protein phosphatase, non-receptor type 5). STEP immunoreactive areas are most intense in the regions of the CNS receiving a dopaminergic input (e.g. striatum, basal ganglia). STEP is part of the NMDA receptor (R) complex and inhibits NMDAR single-channel activity and NMDAR-mediated synaptic current. Phosphorylation of STEP, via D1 and PKA activation by dopamine, decreases the activity of STEP by reducing its affinity for substrate.
Kurup, P., et al. J. Neurosci. 30(17):5948-5957(2010)Rose, J. Phd, et al. Mol. Med. (2010) In press :Korff, S., et al. BMC Cancer 8, 329 (2008) :Eswaran, J., et al. Biochem. J. 395(3):483-491(2006)Nguyen, T.H., et al. J. Biol. Chem. 277(27):24274-24279(2002)
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