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RRM2B Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q7LG56
Clone Names 100525281
Peptide ID 100525281
Additional Information
Gene ID 50484
Other Names Ribonucleoside-diphosphate reductase subunit M2 B, TP53-inducible ribonucleotide reductase M2 B, p53-inducible ribonucleotide reductase small subunit 2-like protein, p53R2, RRM2B, P53R2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RRM2B
Synonyms P53R2
Function Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage.
Cellular Location Cytoplasm. Nucleus. Note=Translocates from cytoplasm to nucleus in response to DNA damage
Tissue Location Widely expressed at a high level in skeletal muscle and at a weak level in thymus. Expressed in epithelial dysplasias and squamous cell carcinoma
Research Areas
Citations (0)

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This gene encodes the small subunit of a p53-inducibleribonucleotide reductase. This heterotetrameric enzyme catalyzesthe conversion of ribonucleoside diphosphates todeoxyribonucleoside diphosphates. The product of this reaction isnecessary for DNA synthesis. Mutations in this gene have beenassociated with autosomal recessive mitochondrial DNA depletionsyndrome, autosomal dominant progressive externalophthalmoplegia-5, and mitochondrial neurogastrointestinalencephalopathy. Alternatively spliced transcript variants have beendescribed.


Zhou, B., et al. Mol. Cancer Ther. 9(6):1669-1679(2010)Smith, P., et al. Biochemistry 48(46):11134-11141(2009)Shaibani, A., et al. Arch. Neurol. 66(8):1028-1032(2009)Tyynismaa, H., et al. Am. J. Hum. Genet. 85(2):290-295(2009)Kollberg, G., et al. Neuromuscul. Disord. 19(2):147-150(2009)

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$ 80.00
Cat# BP17054c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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