|Other Names||Ribonucleoside-diphosphate reductase subunit M2 B, TP53-inducible ribonucleotide reductase M2 B, p53-inducible ribonucleotide reductase small subunit 2-like protein, p53R2, RRM2B, P53R2|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage.|
|Cellular Location||Cytoplasm. Nucleus. Note=Translocates from cytoplasm to nucleus in response to DNA damage|
|Tissue Location||Widely expressed at a high level in skeletal muscle and at a weak level in thymus. Expressed in epithelial dysplasias and squamous cell carcinoma|
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This gene encodes the small subunit of a p53-inducibleribonucleotide reductase. This heterotetrameric enzyme catalyzesthe conversion of ribonucleoside diphosphates todeoxyribonucleoside diphosphates. The product of this reaction isnecessary for DNA synthesis. Mutations in this gene have beenassociated with autosomal recessive mitochondrial DNA depletionsyndrome, autosomal dominant progressive externalophthalmoplegia-5, and mitochondrial neurogastrointestinalencephalopathy. Alternatively spliced transcript variants have beendescribed.
Zhou, B., et al. Mol. Cancer Ther. 9(6):1669-1679(2010)Smith, P., et al. Biochemistry 48(46):11134-11141(2009)Shaibani, A., et al. Arch. Neurol. 66(8):1028-1032(2009)Tyynismaa, H., et al. Am. J. Hum. Genet. 85(2):290-295(2009)Kollberg, G., et al. Neuromuscul. Disord. 19(2):147-150(2009)
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