Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
RRM2B Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q7LG56 |
|---|---|
| Clone Names | 100525281 |
| Gene ID | 50484 |
|---|---|
| Other Names | Ribonucleoside-diphosphate reductase subunit M2 B, TP53-inducible ribonucleotide reductase M2 B, p53-inducible ribonucleotide reductase small subunit 2-like protein, p53R2, RRM2B, P53R2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | RRM2B |
|---|---|
| Synonyms | P53R2 |
| Function | Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. |
| Cellular Location | Cytoplasm. Nucleus. Note=Translocates from cytoplasm to nucleus in response to DNA damage |
| Tissue Location | Widely expressed at a high level in skeletal muscle and at a weak level in thymus. Expressed in epithelial dysplasias and squamous cell carcinoma. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes the small subunit of a p53-inducibleribonucleotide reductase. This heterotetrameric enzyme catalyzesthe conversion of ribonucleoside diphosphates todeoxyribonucleoside diphosphates. The product of this reaction isnecessary for DNA synthesis. Mutations in this gene have beenassociated with autosomal recessive mitochondrial DNA depletionsyndrome, autosomal dominant progressive externalophthalmoplegia-5, and mitochondrial neurogastrointestinalencephalopathy. Alternatively spliced transcript variants have beendescribed.
References
Zhou, B., et al. Mol. Cancer Ther. 9(6):1669-1679(2010)Smith, P., et al. Biochemistry 48(46):11134-11141(2009)Shaibani, A., et al. Arch. Neurol. 66(8):1028-1032(2009)Tyynismaa, H., et al. Am. J. Hum. Genet. 85(2):290-295(2009)Kollberg, G., et al. Neuromuscul. Disord. 19(2):147-150(2009)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
