|Other Names||Protein lin-9 homolog, HuLin-9, hLin-9, Beta subunit-associated regulator of apoptosis, TUDOR gene similar protein, Type I interferon receptor beta chain-associated protein, pRB-associated protein, LIN9, BARA, TGS|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition.|
|Cellular Location||Nucleus, nucleoplasm Note=Found in perinucleolar structures. Associated with chromatin|
|Tissue Location||Expressed in thymus and testis.|
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Provided below are standard protocols that you may find useful for product applications.
LIN9 acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition.
Rose, J. Phd, et al. Mol. Med. (2010) In press :Arking, D.E., et al. PLoS ONE 5 (3), E9879 (2010) :Pilkinton, M., et al. Oncogene 26(54):7535-7543(2007)Osterloh, L., et al. EMBO J. 26(1):144-157(2007)Pilkinton, M., et al. J. Biol. Chem. 282(1):168-175(2007)
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