|Other Names||TGF-beta-activated kinase 1 and MAP3K7-binding protein 3, Mitogen-activated protein kinase kinase kinase 7-interacting protein 3, NF-kappa-B-activating protein 1, TAK1-binding protein 3, TAB-3, TGF-beta-activated kinase 1-binding protein 3, TAB3, MAP3K7IP3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor.|
|Tissue Location||Widely expressed. Constitutively overexpressed in certain tumor tissues. Isoform 1 is a major transcript while isoform 2 is a minor transcript.|
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The product of this gene functions in the NF-kappaB signaltransduction pathway. The encoded protein, and the similar andfunctionally redundant protein MAP3K7IP2/TAB2, forms a ternarycomplex with the protein kinase MAP3K7/TAK1 and either TRAF2 orTRAF6 in response to stimulation with the pro-inflammatorycytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activitytriggers a signaling cascade leading to activation of the NF-kappaBtranscription factor. The human genome contains a relatedpseudogene. Alternatively spliced transcript variants have beendescribed, but their biological validity has not been determined.
Besse, A., et al. J. Biol. Chem. 282(6):3918-3928(2007)Kanayama, A., et al. Mol. Cell 15(4):535-548(2004)Jin, G., et al. Proc. Natl. Acad. Sci. U.S.A. 101(7):2028-2033(2004)Cheung, P.C., et al. Biochem. J. 378 (PT 1), 27-34 (2004) :Bouwmeester, T., et al. Nat. Cell Biol. 6(2):97-105(2004)
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