|Other Names||C-C motif chemokine 27, CC chemokine ILC, Cutaneous T-cell-attracting chemokine, CTACK, ESkine, IL-11 R-alpha-locus chemokine, Skinkine, Small-inducible cytokine A27, CCL27, ILC, SCYA27|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. Binds to CCR10.|
|Tissue Location||Testis, thymus, placenta, ovary and skin.|
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This gene is one of several CC cytokine genes clustered onthe p-arm of chromosome 9. Cytokines are a family of secretedproteins involved in immunoregulatory and inflammatory processes.The CC cytokines are proteins characterized by two adjacentcysteines. The protein encoded by this gene is chemotactic forskin-associated memory T lymphocytes. This cytokine may also play arole in mediating homing of lymphocytes to cutaneous sites. Itspecifically binds to chemokine receptor 10 (CCR10). Studies of asimilar murine protein indicate that these protein-receptorinteractions have a pivotal role in T cell-mediated skininflammation.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Siezen, C.L., et al. Pediatr. Infect. Dis. J. 28(4):333-335(2009)Narbutt, J., et al. Mediators Inflamm. 2009, 269541 (2009) :
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