|Other Names||Heterogeneous nuclear ribonucleoprotein H3, hnRNP H3, Heterogeneous nuclear ribonucleoprotein 2H9, hnRNP 2H9, HNRNPH3, HNRPH3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the splicing process and participates in early heat shock-induced splicing arrest. Due to their great structural variations the different isoforms may possess different functions in the splicing reaction.|
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This gene belongs to the subfamily of ubiquitouslyexpressed heterogeneous nuclear ribonucleoproteins (hnRNPs). ThehnRNPs are RNA binding proteins and they complex with heterogeneousnuclear RNA (hnRNA). These proteins are associated with pre-mRNAsin the nucleus and appear to influence pre-mRNA processing andother aspects of mRNA metabolism and transport. While all of thehnRNPs are present in the nucleus, some seem to shuttle between thenucleus and the cytoplasm. The hnRNP proteins have distinct nucleicacid binding properties. The protein encoded by this gene has tworepeats of quasi-RRM domains that bind to RNAs. It is localized innuclear bodies of the nucleus. This protein is involved in thesplicing process and it also participates in early heatshock-induced splicing arrest by transiently leaving the hnRNPcomplexes. Several alternatively spliced transcript variants havebeen noted for this gene, however, not all are fully characterized.
Miyasaka, T., et al. Cancer Sci. 99(4):755-761(2008)Rikova, K., et al. Cell 131(6):1190-1203(2007)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)
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