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TULP1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O00294 |
|---|---|
| Clone Names | 100712030 |
| Gene ID | 7287 |
|---|---|
| Other Names | Tubby-related protein 1, Tubby-like protein 1, TULP1, TUBL1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TULP1 |
|---|---|
| Synonyms | TUBL1 |
| Function | Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long-term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells (By similarity). Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5- bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vitro). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages. |
| Cellular Location | Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Secreted. Synapse. Note=Detected at synapses between photoreceptor cells and second-order neurons. Does not have a cleavable signal peptide and is secreted by an alternative pathway (By similarity). |
| Tissue Location | Retina-specific. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the tubby-like gene family(TULPs). Members of this family have been identified in plants,vertebrates, and invertebrates and encode proteins of unknownfunction. TULP proteins share a conserved C-terminal region ofapproximately 200 amino acid residues. Mutations in this gene maybe associated with retinitis pigmentosa.
References
Clark, G.R., et al. Ophthalmology (2010) In press :Caberoy, N.B., et al. Exp. Cell Res. 316(2):245-257(2010)Abbasi, A.H., et al. Mol. Vis. 14, 675-682 (2008) :Mataftsi, A., et al. Invest. Ophthalmol. Vis. Sci. 48(11):5160-5167(2007)den Hollander, A.I., et al. Arch. Ophthalmol. 125(7):932-935(2007)
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