|Other Names||Y+L amino acid transporter 1, Monocyte amino acid permease 2, MOP-2, Solute carrier family 7 member 7, y(+)L-type amino acid transporter 1, Y+LAT1, y+LAT-1, SLC7A7|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L- arginine in monocytes.|
|Cellular Location||Basolateral cell membrane; Multi-pass membrane protein|
|Tissue Location||Highest expression in kidney and peripheral blood leukocytes. Weaker expression is observed in lung, heart, placenta, spleen, testis and small intestine. Expressed in normal fibroblasts and those from LPI patients. Also expressed in HUVECs, monocytes, retinal pigment epithelial cells, and various carcinoma cell lines, with highest expression in a colon-carcinoma cell line.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is the light subunit of acationic amino acid transporter. This sodium-independenttransporter is formed when the light subunit encoded by this genedimerizes with the heavy subunit transporter protein SLC3A2. Thistransporter is found in epithelial cell membranes where ittransfers cationic and large neutral amino acids from the cell tothe extracellular space. Defects in this gene are a cause oflysinuric protein intolerance (LPI). Several transcript variantsencoding the same protein have been found for this gene. [providedby RefSeq].
Rose, J. Phd, et al. Mol. Med. (2010) In press :Font-Llitjos, M., et al. Eur. J. Hum. Genet. 17(1):71-79(2009)Broer, S. Physiol. Rev. 88(1):249-286(2008)Sperandeo, M.P., et al. Hum. Mutat. 29(1):14-21(2008)Cimbalistiene, L., et al. J. Appl. Genet. 48(3):277-280(2007)
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