|Other Names||60S ribosomal protein L10a, CSA-19, Neural precursor cell expressed developmentally down-regulated protein 6, NEDD-6, RPL10A, NEDD6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the large ribosomal subunit.|
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Provided below are standard protocols that you may find useful for product applications.
Ribosomes, the organelles that catalyze protein synthesis,consist of a small 40S subunit and a large 60S subunit. Togetherthese subunits are composed of 4 RNA species and approximately 80structurally distinct proteins. This gene encodes a ribosomalprotein that is a component of the 60S subunit. The protein belongsto the L1P family of ribosomal proteins. It is located in thecytoplasm. The expression of this gene is downregulated in thethymus by cyclosporin-A (CsA), an immunosuppressive drug. Studiesin mice have shown that the expression of the ribosomal proteinL10a gene is downregulated in neural precursor cells duringdevelopment. This gene previously was referred to as NEDD6 (neuralprecursor cell expressed, developmentally downregulated 6), but ithas been renamed RPL10A (ribosomal protein 10a). As is typical forgenes encoding ribosomal proteins, there are multiple processedpseudogenes of this gene dispersed through the genome. [provided byRefSeq].
Andersen, J.S., et al. Nature 433(7021):77-83(2005)Kapp, L.D., et al. Annu. Rev. Biochem. 73, 657-704 (2004) :Mungall, A.J., et al. Nature 425(6960):805-811(2003)Mazumder, B., et al. Cell 115(2):187-198(2003)Odintsova, T.I., et al. J. Protein Chem. 22(3):249-258(2003)
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