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FAM107A Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O95990 |
|---|---|
| Clone Names | 100712114 |
| Gene ID | 11170 |
|---|---|
| Other Names | Protein FAM107A, Down-regulated in renal cell carcinoma 1, Protein TU3A, FAM107A, DRR1, TU3A |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | FAM107A (HGNC:30827) |
|---|---|
| Function | Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F- actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory (By similarity). Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner (PubMed:20543869). Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-dependent manner (PubMed:10564580, PubMed:28604741). May play a role in tumor development (PubMed:10564580). |
| Cellular Location | Nucleus. Cytoplasm, cytoskeleton, stress fiber. Cell junction, focal adhesion. Cell projection, ruffle membrane. Synapse {ECO:0000250|UniProtKB:Q78TU8}. Note=Colocalizes with F-actin and COMMD1 in the nucleus (PubMed:28604741). Colocalizes with MAP1A along actin stress fibers and membrane ruffles (PubMed:20543869) |
| Tissue Location | Widely expressed (PubMed:10564580). Expressed in neurons (PubMed:20543869). Expressed in malignant glial tumors (PubMed:20543869). Expression is reduced or absent in a number of cancer cell lines (PubMed:10564580). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
When transfected into cell lines in which it is not expressed, suppresses cell growth. May play a role in tumor development.
References
Stahl, E.A., et al. Nat. Genet. 42(6):508-514(2010)Asano, Y., et al. Biochem. Biophys. Res. Commun. 394(3):829-835(2010)Awakura, Y., et al. Int. J. Oncol. 33(4):893-899(2008)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Kholodnyuk, I.D., et al. Int. J. Cancer 119(1):99-107(2006)
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