|Other Names||Gamma-aminobutyric acid receptor subunit epsilon, GABA(A) receptor subunit epsilon, GABRE|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.|
|Cellular Location||Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in many tissues. Highest levels of expression in adult heart and placenta|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene belongs to the ligand-gated ionicchannel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid(GABA) A receptor which is a multisubunit chloride channel thatmediates the fastest inhibitory synaptic transmission in thecentral nervous system. This gene encodes an epsilon subunit. It ismapped to chromosome Xq28 in a cluster comprised of genes encodingalpha 3, beta 4 and theta subunits of the same receptor.Alternatively spliced transcript variants have been identified, butonly one is thought to encode a protein.
Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :Craddock, N., et al. Mol. Psychiatry 15(2):146-153(2010)Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :Tabakoff, B., et al. BMC Biol. 7, 70 (2009) :Fernandez, F., et al. BMC Med. Genet. 9, 109 (2008) :
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