|Other Names||Interferon-induced protein with tetratricopeptide repeats 2, IFIT-2, ISG-54 K, Interferon-induced 54 kDa protein, IFI-54K, P54, IFIT2, CIG-42, G10P2, IFI54, ISG54|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CIG-42, G10P2, IFI54, ISG54|
|Function||IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O- methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.|
|Cellular Location||Cytoplasm. Endoplasmic reticulum|
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Provided below are standard protocols that you may find useful for product applications.
Lai, K.C., et al. Mol. Cancer Res. 6(9):1431-1439(2008)Terenzi, F., et al. J. Biol. Chem. 281(45):34064-34071(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)Saha, S., et al. J. Gen. Virol. 87 (PT 11), 3285-3289 (2006) :Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
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