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IFIT2 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P09913
Other Accession NP_001538.4
Clone Names 100712150
Peptide ID 100712150
Additional Information
Gene ID 3433
Other Names Interferon-induced protein with tetratricopeptide repeats 2, IFIT-2, ISG-54 K, Interferon-induced 54 kDa protein, IFI-54K, P54, IFIT2, CIG-42, G10P2, IFI54, ISG54
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name IFIT2
Synonyms CIG-42, G10P2, IFI54, ISG54
Function IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O- methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.
Cellular Location Cytoplasm. Endoplasmic reticulum
Research Areas
Citations (0)

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Lai, K.C., et al. Mol. Cancer Res. 6(9):1431-1439(2008)Terenzi, F., et al. J. Biol. Chem. 281(45):34064-34071(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)Saha, S., et al. J. Gen. Virol. 87 (PT 11), 3285-3289 (2006) :Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)

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$ 80.00
Cat# BP17102c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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