|Other Names||Cytosolic non-specific dipeptidase, CNDP dipeptidase 2, Glutamate carboxypeptidase-like protein 1, Peptidase A, CNDP2, CN2, CPGL, PEPA|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CN2, CPGL, PEPA|
|Function||Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Isoform 2 may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells.|
|Tissue Location||Isoform 1 is ubiquitously expressed with higher levels in kidney and liver (at protein level). Isoform 2 is expressed in fetal tissues, it is only expressed in adult liver and placental tissues.|
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Provided below are standard protocols that you may find useful for product applications.
CNDP2, also known as tissue carnosinase and peptidase A(EC 188.8.131.52), is a nonspecific dipeptidase rather than aselective carnosinase (Teufel et al., 2003 [PubMed12473676]).
Ahmed, A.H., et al. Biochemistry 49(13):2843-2850(2010)McDonough, C.W., et al. Hum. Genet. 126(2):265-275(2009)Wanic, K., et al. Diabetes 57(9):2547-2551(2008)Wanic, K., et al. Diabetes (2008) In press :Tu, L.C., et al. Mol. Cell Proteomics 6(4):575-588(2007)
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