|Other Names||Cytosolic non-specific dipeptidase, CNDP dipeptidase 2, Glutamate carboxypeptidase-like protein 1, Peptidase A, CNDP2, CN2, CPGL, PEPA|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly (PubMed:19346245). Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway. An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower level of CNDP2 activates the ERK MAPK pathway to promote cell proliferation (PubMed:24395568). Isoform 2 may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells (PubMed:17121880). Catalyzes the production of N- lactoyl-amino acids from lactate and amino acids by reverse proteolysis (PubMed:25964343).|
|Tissue Location||Isoform 1 is ubiquitously expressed with higher levels in kidney and liver (at protein level). Expressed in peripheral blood leukocytes (PubMed:12473676). Isoform 2 is expressed in fetal tissues, it is only expressed in adult liver and placental tissues. Down-regulated in gastric cancer tissues (at protein level) (PubMed:24395568)|
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Provided below are standard protocols that you may find useful for product applications.
CNDP2, also known as tissue carnosinase and peptidase A(EC 22.214.171.124), is a nonspecific dipeptidase rather than aselective carnosinase (Teufel et al., 2003 [PubMed12473676]).
Ahmed, A.H., et al. Biochemistry 49(13):2843-2850(2010)McDonough, C.W., et al. Hum. Genet. 126(2):265-275(2009)Wanic, K., et al. Diabetes 57(9):2547-2551(2008)Wanic, K., et al. Diabetes (2008) In press :Tu, L.C., et al. Mol. Cell Proteomics 6(4):575-588(2007)
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