CNDP2 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q96KP4 |
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Clone Names | 110726036 |
Gene ID | 55748 |
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Other Names | Cytosolic non-specific dipeptidase, CNDP dipeptidase 2, Glutamate carboxypeptidase-like protein 1, Peptidase A, CNDP2, CN2, CPGL, PEPA |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | CNDP2 {ECO:0000303|PubMed:25964343, ECO:0000312|HGNC:HGNC:24437} |
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Function | Catalyzes the peptide bond hydrolysis in dipeptides, displaying a non-redundant activity toward threonyl dipeptides (By similarity). Mediates threonyl dipeptide catabolism in a tissue- specific way (By similarity). Has high dipeptidase activity toward cysteinylglycine, an intermediate metabolite in glutathione metabolism (PubMed:19346245, PubMed:12473676). Metabolizes N-lactoyl-amino acids, both through hydrolysis to form lactic acid and amino acids, as well as through their formation by reverse proteolysis (PubMed:25964343). Plays a role in the regulation of cell cycle arrest and apoptosis (PubMed:17121880, PubMed:24395568). |
Cellular Location | Cytoplasm |
Tissue Location | [Isoform 1]: Ubiquitously expressed with higher levels in kidney and liver (at protein level). Expressed in peripheral blood leukocytes (PubMed:12473676). Expressed in gastric mucosa and down-regulated in gastric cancer mucosal tissues (at protein level) (PubMed:24395568). |
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Provided below are standard protocols that you may find useful for product applications.
Background
CNDP2, also known as tissue carnosinase and peptidase A(EC 3.4.13.18), is a nonspecific dipeptidase rather than aselective carnosinase (Teufel et al., 2003 [PubMed12473676]).
References
Ahmed, A.H., et al. Biochemistry 49(13):2843-2850(2010)McDonough, C.W., et al. Hum. Genet. 126(2):265-275(2009)Wanic, K., et al. Diabetes 57(9):2547-2551(2008)Wanic, K., et al. Diabetes (2008) In press :Tu, L.C., et al. Mol. Cell Proteomics 6(4):575-588(2007)
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