|Other Names||Bone morphogenetic protein 1, BMP-1, Mammalian tolloid protein, mTld, Procollagen C-proteinase, PCP, BMP1, PCOLC|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1712a was selected from the C-term region of human Bmp1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD). Responsible for the proteolytic activation of lysyl oxidase LOX.|
|Cellular Location||Golgi apparatus, trans-Golgi network. Secreted, extracellular space, extracellular matrix. Note=Co- localizes with POSTN in the Golgi.|
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Provided below are standard protocols that you may find useful for product applications.
The BMP1 locus encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, BMP1 encodes a protein that is not closely related to other known growth factors. BMP1 protein and procollagen C proteinase (PCP), a secreted metalloprotease requiring calcium and needed for cartilage and bone formation, are identical. PCP or BMP1 protein cleaves the C-terminal propeptides of procollagen I, II, and III and its activity is increased by the procollagen C-endopeptidase enhancer protein. The BMP1 gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region.
Leighton, M., et al., J. Biol. Chem. 278(20):18478-18484 (2003).Hartigan, N., et al., J. Biol. Chem. 278(20):18045-18049 (2003).Garrigue-Antar, L., et al., J. Biol. Chem. 277(45):43327-43334 (2002).Rattenholl, A., et al., J. Biol. Chem. 277(29):26372-26378 (2002).Janitz, M., et al., J. Mol. Med. 76(2):141-146 (1998).
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