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CDS2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O95674 |
|---|---|
| Clone Names | 110717026 |
| Gene ID | 8760 |
|---|---|
| Other Names | Phosphatidate cytidylyltransferase 2, CDP-DAG synthase 2, CDP-DG synthase 2, CDP-diacylglycerol synthase 2, CDS 2, CDP-diglyceride pyrophosphorylase 2, CDP-diglyceride synthase 2, CTP:phosphatidate cytidylyltransferase 2, CDS2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CDS2 (HGNC:1801) |
|---|---|
| Function | Catalyzes the conversion of phosphatidic acid (PA) to CDP- diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (PubMed:25375833). Exhibits specificity for the nature of the acyl chains at the sn-1 and sn-2 positions in the substrate, PA and the preferred acyl chain composition is 1-stearoyl-2-arachidonoyl-sn- phosphatidic acid (PubMed:25375833). Plays an important role in regulating the growth and maturation of lipid droplets which are storage organelles at the center of lipid and energy homeostasis (PubMed:26946540, PubMed:31548309). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein |
| Tissue Location | Widely expressed. Expressed in heart, brain and retina, and to a lesser extent in placenta, lung, liver, skeletal muscle, kidney and pancreas. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Breakdown products of phosphoinositides are ubiquitoussecond messengers that function downstream of many Gprotein-coupled receptors and tyrosine kinases regulating cellgrowth, calcium metabolism, and protein kinase C activity. Thisgene encodes an enzyme which regulates the amount ofphosphatidylinositol available for signaling by catalyzing theconversion of phosphatidic acid to CDP-diacylglycerol. This enzymeis an integral membrane protein localized to two subcellulardomains, the matrix side of the inner mitochondrial membrane whereit is thought to be involved in the synthesis ofphosphatidylglycerol and cardiolipin and the cytoplasmic side ofthe endoplasmic reticulum where it functions inphosphatidylinositol biosynthesis. Two genes encoding this enzymehave been identified in humans, one mapping to human chromosome4q21 and a second to 20p13.
References
Bailey, S.D., et al. Diabetes Care (2010) In press :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)
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