|Other Names||Phosphatidate cytidylyltransferase 2, CDP-DAG synthase 2, CDP-DG synthase 2, CDP-diacylglycerol synthase 2, CDS 2, CDP-diglyceride pyrophosphorylase 2, CDP-diglyceride synthase 2, CTP:phosphatidate cytidylyltransferase 2, CDS2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin.|
|Cellular Location||Mitochondrion inner membrane; Multi-pass membrane protein; Matrix side|
|Tissue Location||Widely expressed. Expressed in heart, brain and retina, and to a lesser extent in placenta, lung, liver, skeletal muscle, kidney and pancreas|
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Breakdown products of phosphoinositides are ubiquitoussecond messengers that function downstream of many Gprotein-coupled receptors and tyrosine kinases regulating cellgrowth, calcium metabolism, and protein kinase C activity. Thisgene encodes an enzyme which regulates the amount ofphosphatidylinositol available for signaling by catalyzing theconversion of phosphatidic acid to CDP-diacylglycerol. This enzymeis an integral membrane protein localized to two subcellulardomains, the matrix side of the inner mitochondrial membrane whereit is thought to be involved in the synthesis ofphosphatidylglycerol and cardiolipin and the cytoplasmic side ofthe endoplasmic reticulum where it functions inphosphatidylinositol biosynthesis. Two genes encoding this enzymehave been identified in humans, one mapping to human chromosome4q21 and a second to 20p13.
Bailey, S.D., et al. Diabetes Care (2010) In press :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)
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