|Other Names||DNA-binding protein inhibitor ID-3, Class B basic helix-loop-helix protein 25, bHLHb25, Helix-loop-helix protein HEIR-1, ID-like protein inhibitor HLH 1R21, Inhibitor of DNA binding 3, Inhibitor of differentiation 3, ID3, 1R21, BHLHB25, HEIR1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||1R21, BHLHB25, HEIR1|
|Function||Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer.|
|Tissue Location||Expressed abundantly in lung, kidney and adrenal gland, but not in adult brain|
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Provided below are standard protocols that you may find useful for product applications.
Members of the ID family of helix-loop-helix (HLH)proteins lack a basic DNA-binding domain and inhibit transcriptionthrough formation of nonfunctional dimers that are incapable ofbinding to DNA.
Shuno, Y., et al. J. Surg. Res. 161(1):76-82(2010)Doran, A.C., et al. Circ. Res. 106(7):1303-1311(2010)McGeachie, M., et al. Circulation 120(24):2448-2454(2009)Higgins, S., et al. Endocrinology 150(9):4044-4055(2009)Trabosh, V.A., et al. Exp. Dermatol. 18(4):387-395(2009)
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