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ID3 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q02535
Clone Names 100427290
Peptide ID 100427290
Additional Information
Gene ID 3399
Other Names DNA-binding protein inhibitor ID-3, Class B basic helix-loop-helix protein 25, bHLHb25, Helix-loop-helix protein HEIR-1, ID-like protein inhibitor HLH 1R21, Inhibitor of DNA binding 3, Inhibitor of differentiation 3, ID3, 1R21, BHLHB25, HEIR1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ID3
Synonyms 1R21, BHLHB25, HEIR1
Function Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer.
Cellular Location Nucleus.
Tissue Location Expressed abundantly in lung, kidney and adrenal gland, but not in adult brain
Research Areas
Citations (0)

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Members of the ID family of helix-loop-helix (HLH)proteins lack a basic DNA-binding domain and inhibit transcriptionthrough formation of nonfunctional dimers that are incapable ofbinding to DNA.


Shuno, Y., et al. J. Surg. Res. 161(1):76-82(2010)Doran, A.C., et al. Circ. Res. 106(7):1303-1311(2010)McGeachie, M., et al. Circulation 120(24):2448-2454(2009)Higgins, S., et al. Endocrinology 150(9):4044-4055(2009)Trabosh, V.A., et al. Exp. Dermatol. 18(4):387-395(2009)

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$ 80.00
Cat# BP17144a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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