|Other Names||Carcinoembryonic antigen-related cell adhesion molecule 7, Carcinoembryonic antigen CGM2, CEACAM7, CGM2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor. Apical cell membrane. Note=Localized to the apical glycocalyx surface.|
|Tissue Location||Expressed in columnar epithelial cells of the colon (at protein level) (PubMed:10436421). Strongly down- regulated in colonic adenocarcinomas|
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CEA-related cell adhesion molecule 7 (CEACAM7,CGM2) belongs to the carcinoembryonic antigen (CEA) family. It encodes a glycosyl phosphatidyl inositol (GPI)-linked glycoprotein which is only found on the apical surface of highly differentiated epithelial cells adult colon and on a small epithelial cell population in pancreatic ducts. CEACAM7 expression is completely lost upon malignant transformation already in hyperplastic polyps and early adenomas as well as in adenocarcinomas of the colon. Like all members of the CEACAM family, it consists of a single N domain, with structural homology to the immunoglobulin variable domains, followed by one immunoglobulin constantlike A domain.
Messick, C.A., et al. Surgery 147(5):713-719(2010)Douard, R., et al. Surgery 139(4):556-562(2006)Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)Grimwood, J., et al. Nature 428(6982):529-535(2004)Scholzel, S., et al. Am. J. Pathol. 156(2):595-605(2000)
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