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PPT1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P50897 |
|---|---|
| Clone Names | 100617087 |
| Gene ID | 5538 |
|---|---|
| Other Names | Palmitoyl-protein thioesterase 1, PPT-1, Palmitoyl-protein hydrolase 1, PPT1, PPT |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PPT1 |
|---|---|
| Synonyms | CLN1 {ECO:0000303|PubMed:19941651}, PPT |
| Function | Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons (PubMed:8816748). |
| Cellular Location | Lysosome. Secreted {ECO:0000250|UniProtKB:P45478} |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a small glycoproteininvolved in the catabolism of lipid-modified proteins duringlysosomal degradation. The encoded enzyme removes thioester-linkedfatty acyl groups such as palmitate from cysteine residues. Defectsin this gene are a cause of infantile neuronal ceroidlipofuscinosis 1 (CLN1, or INCL) and neuronal ceroid lipofuscinosis4 (CLN4). Two transcript variants encoding different isoforms havebeen found for this gene.
References
Ohno, K., et al. Brain Dev. 32(7):524-530(2010)Simonati, A., et al. Pediatr. Neurol. 40(4):271-276(2009)Martins-de-Souza, D., et al. Eur Arch Psychiatry Clin Neurosci 259(3):151-163(2009)Kousi, M., et al. Brain 132 (PT 3), 810-819 (2009) :Gregorio, S.P., et al. Psychiatry Res 165 (1-2), 1-9 (2009) :
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