|Other Names||Calcium-transporting ATPase type 2C member 1, ATPase 2C1, ATP-dependent Ca(2+) pump PMR1, ATP2C1, KIAA1347, PMR1L|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium.|
|Cellular Location||Golgi apparatus membrane; Multi-pass membrane protein|
|Tissue Location||Found in most tissues except colon, thymus, spleen and leukocytes. Most abundant in keratinocytes and kidney|
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The protein encoded by this gene belongs to the family ofP-type cation transport ATPases. This magnesium-dependent enzymecatalyzes the hydrolysis of ATP coupled with the transport of thecalcium. Defects in this gene cause Hailey-Hailey disease, anautosomal dominant disorder. Alternatively spliced transcriptvariants encoding different isoforms have been identified.
Baron, S., et al. Biochim. Biophys. Acta 1798(8):1512-1521(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Tian, H., et al. J. Dermatol. Sci. 58(1):80-82(2010)Ding, Y.G., et al. Clin. Exp. Dermatol. 34 (8), E968-E971 (2009) :Nechama, M., et al. BMC Cell Biol. 10, 70 (2009) :
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